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Substance use is a complex issue, with many causes and manifestations. It is a widespread and costly problem to individuals, families, communities, and governments across Canada. Sex and gender are biological and social determinants of health, respectively, that affect everyone’s health. Incorporating sex and gender into our responses to substance use will lead to better practice, and is now expected by funders and the public. This handbook is focused on 10 key questions that illustrate the impact that sex and gender have on substance use, and indicate how this knowledge can inform more tailored responses by service providers and policy makers. View PDF